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NDB ID: 5V1L    PDB ID: 5V1L 


Title:

STRUCTURE OF S-GNA DODECAMER

Molecular Description:

Modified RNA dodecamer

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Schlegel, M.K., Foster, D.J., Kel'in, A.V., Zlatev, I., Bisbe, A., Jayaraman, M., Lackey, J.G., Rajeev, K.G., Charisse, K., Harp, J., Pallan, P.S., Maier, M.A., Egli, M., Manoharan, M.
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. 
J. Am. Chem. Soc., 139, pp. 8537 - 8546, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 34.951   b = 46.239   c = 82.928 (Ångstroms)

α = 90.0   β = 100.09   γ = 90.0 (degrees)

Refinement:

The structure was refined using the SHELXL program. The R value is 0.0 for 0 reflections in the resolution range 27.6 to 1.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)