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NDB ID: 5V2H    PDB ID: 5V2H 


Title:

RNA OCTAMER CONTAINING GLYCOL NUCLEIC ACID, SGNT

Molecular Description:

RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3')

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Schlegel, M.K., Foster, D.J., Kel'in, A.V., Zlatev, I., Bisbe, A., Jayaraman, M., Lackey, J.G., Rajeev, K.G., Charisse, K., Harp, J., Pallan, P.S., Maier, M.A., Egli, M., Manoharan, M.
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. 
J. Am. Chem. Soc., 139, pp. 8537 - 8546, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 79.029   b = 31.901   c = 33.782 (Ångstroms)

α = 90.0   β = 90.461   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.136637 for 35373 reflections in the resolution range 33.7809 to 1.08001 Ångstroms with Fobs >  1.42213 sigma(Fobs) and with I >  0.0 sigma(I)