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NDB ID: 5VMY    PDB ID: 5VMY 


Title:

KAISO (ZBTB33) ZINC FINGER DNA BINDING DOMAIN IN COMPLEX WITH A HEMI CPG-METHYLATED DNA RESEMBLING THE SPECIFIC KAISO BINDING SEQUENCE (KBS)

Molecular Description:

Transcriptional regulator Kaiso/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Nikolova, E.N., Stanfield, R.L., Dyson, H.J., Wright, P.E.
CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. 
Biochemistry, 57, pp. 2109 - 2120, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 2

Cell Constants:

a = 44.276   b = 183.605   c = 105.033 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1661 for 28931 reflections in the resolution range 43.042 to 2.002 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)