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NDB ID: 5VOE    PDB ID: 5VOE 


Title:

DESGLA-XAS195A BOUND TO APTAMER 11F7T

Molecular Description:

Coagulation factor X/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Gunaratne, R., Kumar, S., Frederiksen, J.W., Stayrook, S., Lohrmann, J.L., Perry, K., Bompiani, K.M., Chabata, C.V., Thalji, N.K., Ho, M.D., Arepally, G., Camire, R.M., Krishnaswamy, S., Sullenger, B.A.
Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. 
Nat. Biotechnol., 36, pp. 606 - 613, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 55.916   b = 164.596   c = 124.646 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.21476 for 36141 reflections in the resolution range 82.3 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)