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NDB ID: 5VR4    PDB ID: 5VR4 


Title:

RNA OCTAMER CONTAINING 2'-F-4'-OME U.

Molecular Description:

RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3')

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Malek-Adamian, E., Guenther, D.C., Matsuda, S., Martinez-Montero, S., Zlatev, I., Harp, J., Burai Patrascu, M., Foster, D.J., Fakhoury, J., Perkins, L., Moitessier, N., Manoharan, R.M., Taneja, N., Bisbe, A., Charisse, K., Maier, M., Rajeev, K.G., Egli, M., Manoharan, M., Damha, M.J.
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. 
J. Am. Chem. Soc., 139, pp. 14542 - 14555, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 44.387   b = 44.387   c = 85.921 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.189 for 26152 reflections in the resolution range 29.481 to 1.5 Ångstroms with Fobs >  0.17 sigma(Fobs) and with I >  0.0 sigma(I)