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NDB ID: 5WEA    PDB ID: 5WEA 


Title:

HUMAN ARGONAUTE2 HELIX-7 MUTANT

Molecular Description:

Protein argonaute-2/RNA Complex

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Klum, S.M., Chandradoss, S.D., Schirle, N.T., Joo, C., MacRae, I.J.
Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. 
EMBO J., , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 63.261   b = 107.88   c = 68.723 (Ångstroms)

α = 90.0   β = 107.46   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2537 for 14815 reflections in the resolution range 65.555 to 3.12 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)