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NDB ID: 5XF5    PDB ID: 5XF5 


Title:

NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (R,S-CONFIGURATION)

Molecular Description:

Histone H3.1
Histone H4
Histone H2A type 1-B/E
Histone H2B type 1-J/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S., Dyson, P.J., Davey, C.A.
Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation 
Nat Commun, 8, pp. 1575 - 1575, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 107.21   b = 109.67   c = 182.04 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.22847 for 51315 reflections in the resolution range 70.65 to 2.82 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)