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NDB ID: 5XI1    PDB ID: 5XI1 


Title:

STRUCTURAL INSIGHT OF FLAVONOIDS BINDING TO CAG REPEAT RNA THAT CAUSES HUNTINGTON'S DISEASE (HD) AND SPINOCEREBELLAR ATAXIA (SCAS)

Molecular Description:

RNA (5'-R(P*CP*CP*GP*CP*AP*GP*CP*GP*G)-3')

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Khan, E., Tawani, A., Mishra, S.K., Verma, A.K., Upadhyay, A., Kumar, M., Sandhir, R., Mishra, A., Kumar, A.
Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs). 
ACS Chem. Biol., 13, pp. 180 - 188, 2018.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Number of Models:

Number of Models: 10 Structures

Sample Details:

1.54 mM RNA (5'-R(P*CP*CP*GP*CP*AP*GP*CP*GP*G)-3'), 3.08 mM MYC, 90% H2O/10% D2O 90% H2O/10% D2O