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NDB ID: 5Y0D    PDB ID: 5Y0D     NAKB(beta): 5Y0D 


Title:

CRYSTAL STRUCTURE OF THE HUMAN NUCLEOSOME CONTAINING THE H2B E76K MUTANT

Molecular Description:

Histone H3.1
Histone H4
Histone H2A type 1-B/E
Histone H2B type 1-J/DNA Complex

Deposited:

2017-07-16

Released:

2018-07-18

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Arimura, Y., Ikura, M., Fujita, R., Noda, M., Kobayashi, W., Horikoshi, N., Sun, J., Shi, L., Kusakabe, M., Harata, M., Ohkawa, Y., Tashiro, S., Kimura, H., Ikura, T., Kurumizaka, H.
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. 
Nucleic Acids Res., 46, pp. 10007 - 10018, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 98.992   b = 107.316   c = 167.719 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2127 for 118684 reflections in the resolution range 49.582 to 1.99 Ångstroms with Fobs >  1.39 sigma(Fobs) and with I >  0.0 sigma(I)