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NDB ID: 5Z1H    PDB ID: 5Z1H 


Title:

CRYSTAL STRUCTURE OF THE BACTERIAL RIBOSOMAL DECODING SITE IN COMPLEX WITH 6'-FLUORO SISOMICIN

Molecular Description:

RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3')

Structural Keywords:

A DOUBLE HELIX, FLIPPED OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kanazawa, H., Saavedra, O.M., Maianti, J.P., Young, S.A., Izquierdo, L., Smith, T.K., Hanessian, S., Kondo, J.
Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. 
ChemMedChem, , pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 42.905   b = 31.665   c = 46.696 (Ångstroms)

α = 90.0   β = 94.82   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2171 for 5047 reflections in the resolution range 42.8 to 2.4 Ångstroms with Fobs >  1.38 sigma(Fobs) and with I >  0.0 sigma(I)