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NDB ID: 5Z1I    PDB ID: 5Z1I 


Title:

CRYSTAL STRUCTURE OF THE PROTOZOAL CYTOPLASMIC RIBOSOMAL DECODING SITE IN COMPLEX WITH 6'-FLUORO SISOMICIN

Molecular Description:

RNA (5'-R(P*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3')

Structural Keywords:

A DOUBLE HELIX, FLIPPED OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kanazawa, H., Saavedra, O.M., Maianti, J.P., Young, S.A., Izquierdo, L., Smith, T.K., Hanessian, S., Kondo, J.
Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. 
ChemMedChem, 13, pp. 1541 - 1548, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 4 2 2

Cell Constants:

a = 46.171   b = 46.171   c = 115.294 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.0 for 5223 reflections in the resolution range 42.862 to 1.903 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)