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NDB ID: 5Z30    PDB ID: 5Z30 


Title:

THE CRYSTAL STRUCTURE OF THE NUCLEOSOME CONTAINING A CANCER-ASSOCIATED HISTONE H2A.Z R80C MUTANT

Molecular Description:

Histone H3.1
Histone H4
Histone H2A.Z
Histone H2B type 1-J/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Arimura, Y., Ikura, M., Fujita, R., Noda, M., Kobayashi, W., Horikoshi, N., Sun, J., Shi, L., Kusakabe, M., Harata, M., Ohkawa, Y., Tashiro, S., Kimura, H., Ikura, T., Kurumizaka, H.
Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. 
Nucleic Acids Res., , pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 99.399   b = 108.332   c = 170.902 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2036 for 66581 reflections in the resolution range 49.7 to 2.45 Ångstroms with Fobs >  1.41 sigma(Fobs) and with I >  0.0 sigma(I)