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NDB ID: 5ZC9    PDB ID: 5ZC9 


Title:

CRYSTAL STRUCTURE OF THE HUMAN EIF4A1-ATP ANALOG-ROCA-POLYPURINE RNA COMPLEX

Molecular Description:

Eukaryotic initiation factor 4A-I/RNA Complex

Deposited:

2018-02-16

Released:

2019-01-16

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Iwasaki, S., Iwasaki, W., Takahashi, M., Sakamoto, A., Watanabe, C., Shichino, Y., Floor, S.N., Fujiwara, K., Mito, M., Dodo, K., Sodeoka, M., Imataka, H., Honma, T., Fukuzawa, K., Ito, T., Ingolia, N.T.
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA. 
Mol. Cell, 73, pp. 738 - , 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 68.508   b = 100.263   c = 155.422 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1949 for 36502 reflections in the resolution range 45.733 to 2.0 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)