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NDB ID: 5ZEN    PDB ID: 5ZEN 


Title:

CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE

Molecular Description:

DNA topoisomerase 2-beta/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chen, S.F., Huang, N.L., Lin, J.H., Wu, C.C., Wang, Y.R., Yu, Y.J., Gilson, M.K., Chan, N.L.
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. 
Nat Commun, 9, pp. 3085 - 3085, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 95.76   b = 95.76   c = 231.055 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.224 for 32531 reflections in the resolution range 19.97 to 2.75 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)