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NDB ID: 5ZEV    PDB ID: 5ZEV 


Title:

SOLUTION STRUCTURE OF G-QUADRUPLEX FORMED IN VEGFR-2 PROXIMAL PROMOTER SEQUENCE

Molecular Description:

DNA (5'-D(*GP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*TP*GP*AP*GP*GP*TP*GP*CP*GP*GP*GP*GP*T)-3')

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Liu, Y., Lan, W., Wang, C., Cao, C.
A putative G-quadruplex structure in the proximal promoter ofVEGFR-2has implications for drug design to inhibit tumor angiogenesis. 
J. Biol. Chem., 293, pp. 8947 - 8955, 2018.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Number of Models:

Number of Models: 20 Structures

Sample Details:

1 mM DNA (5'-D(*GP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*TP*GP*AP*GP*GP*TP*GP*CP*GP*GP*GP*GP*T)-3'), 20 mM potassium phosphate, 80 mM potassium chloride, 90% H2O/10% D2O 90% H2O/10% D2O