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NDB ID: 5ZMC    PDB ID: 5ZMC 


Title:

STRUCTURAL BASIS FOR REACTIVATION OF -146C>T MUTANT TERT PROMOTER BY COOPERATIVE BINDING OF P52 AND ETS1/2

Molecular Description:

Protein C-ets-1
Nuclear factor NF-kappa-B p100 subunit/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Xu, X., Li, Y., Bharath, S.R., Ozturk, M.B., Bowler, M.W., Loo, B.Z.L., Tergaonkar, V., Song, H.
Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. 
Nat Commun, 9, pp. 3183 - 3183, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 2 2

Cell Constants:

a = 71.414   b = 71.414   c = 262.52 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.26043 for 12379 reflections in the resolution range 71.41 to 2.99 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)