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NDB ID: 5ZRF    PDB ID: 5ZRF 


Title:

CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5-IODOURIDINE-CONTAINING-DNA AND ETOPOSIDE IN SPACE GROUP P21

Molecular Description:

DNA topoisomerase 2-beta/DNA Complex

Deposited:

2018-04-24

Released:

2018-08-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chen, S.F., Huang, N.L., Lin, J.H., Wu, C.C., Wang, Y.R., Yu, Y.J., Gilson, M.K., Chan, N.L.
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. 
Nat Commun, 9, pp. 3085 - 3085, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 80.147   b = 176.27   c = 94.331 (Ångstroms)

α = 90.0   β = 111.44   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1894 for 99750 reflections in the resolution range 19.869 to 2.3 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)