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NDB ID: 5DEU    PDB ID: 5DEU 


Title:

CRYSTAL STRUCTURE OF TET2-5HMC COMPLEX

Molecular Description:

Methylcytosine dioxygenase TET2/DNA Complex

Deposited:

2015-08-26

Released:

2015-11-04

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hu, L., Lu, J., Cheng, J., Rao, Q., Li, Z., Hou, H., Lou, Z., Zhang, L., Li, W., Gong, W., Liu, M., Sun, C., Yin, X., Li, J., Tan, X., Wang, P., Wang, Y., Fang, D., Cui, Q., Yang, P., He, C., Jiang, H., Luo, C., Xu, Y.
Structural insight into substrate preference for TET-mediated oxidation. 
Nature, 527, pp. 118 - 122, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 48.262   b = 87.522   c = 260.864 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1785 for 50686 reflections in the resolution range 42.262 to 1.801 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)