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NDB ID: 5IIM    PDB ID: 5IIM 


Title:

CRYSTAL STRUCTURE OF THE PRE-CATALYTIC TERNARY EXTENSION COMPLEX OF DNA POLYMERASE LAMBDA WITH AN 8-OXO-DG:DA BASE-PAIR

Molecular Description:

DNA polymerase lambda/DNA Complex

Deposited:

2016-03-01

Released:

2016-09-07

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Burak, M.J., Guja, K.E., Hambardjieva, E., Derkunt, B., Garcia-Diaz, M.
A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG. 
Embo J., 35, pp. 2045 - 2059, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 56.274   b = 63.7   c = 140.725 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1866 for 36076 reflections in the resolution range 43.947 to 1.941 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)