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NDB ID: 6AK9    PDB ID: 6AK9 


Title:

PRE-CATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE MU WITH TEMPLATING CYTOSINE AND INCOMING CA-8OXODGTP

Molecular Description:

DNA-directed DNA/RNA polymerase mu (E.C.2.7.7.7)

Deposited:

2018-08-30

Released:

2019-05-29

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chang, Y.K., Huang, Y.P., Liu, X.X., Ko, T.P., Bessho, Y., Kawano, Y., Maestre-Reyna, M., Wu, W.J., Tsai, M.D.
Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. 
J.Am.Chem.Soc., 141, pp. 8489 - 8502, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 59.907   b = 68.742   c = 110.211 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.16699 for 34340 reflections in the resolution range 30.0 to 1.91 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)