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NDB ID: 6ANQ    PDB ID: 6ANQ 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 8.5

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Martinez, S.E., Bauman, J.D., Das, K., Arnold, E.
Structure of HIV-1 reverse transcriptase/d4TTP complex: novel DNA cross-linking site and pH-dependent conformational changes. 
Protein Sci., , pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.853   b = 132.723   c = 139.471 (Ångstroms)

α = 90.0   β = 98.06   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1803 for 100068 reflections in the resolution range 43.445 to 2.586 Ångstroms with Fobs >  1.39 sigma(Fobs) and with I >  0.0 sigma(I)