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NDB ID: 6AU4    PDB ID: 6AU4 


Title:

CRYSTAL STRUCTURE OF THE MAJOR QUADRUPLEX FORMED IN THE HUMAN C-MYC PROMOTER

Molecular Description:

DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3')

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Stump, S., Mou, T.C., Sprang, S.R., Natale, N.R., Beall, H.D.
First crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 65.663   b = 69.811   c = 32.952 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2229 for 6624 reflections in the resolution range 34.906 to 2.35 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)