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NDB ID: 6AVT    PDB ID: 6AVT 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO FIRST BASE TEMPLATE OVERHANG

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Martinez, S.E., Das, K., Arnold, E.
HIV-1 Reverse Transcriptase in Complex with d4TTP at pH 7.0 to 9.5 Shows Conformational Change Consistent with pH Dependence of Activity
To be published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 90.197   b = 133.504   c = 140.129 (Ångstroms)

α = 90.0   β = 97.49   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1795 for 99712 reflections in the resolution range 25.892 to 2.603 Ångstroms with Fobs >  1.38 sigma(Fobs) and with I >  0.0 sigma(I)