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NDB ID: 6BKF    PDB ID: 6BKF 


Title:

LYSYL-ADENYLATE FORM OF HUMAN LIGIV CATALYTIC DOMAIN WITH BOUND DNA SUBSTRATE IN OPEN CONFORMATION

Molecular Description:

DNA ligase 4/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kaminski, A.M., Tumbale, P.P., Schellenberg, M.J., Williams, R.S., Williams, J.G., Kunkel, T.A., Pedersen, L.C., Bebenek, K.
Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. 
Nat Commun, 9, pp. 2642 - 2642, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 119.22   b = 119.22   c = 137.414 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2664 for 14106 reflections in the resolution range 37.701 to 3.25 Ångstroms with Fobs >  1.45 sigma(Fobs) and with I >  0.0 sigma(I)