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NDB ID: 6BM4    PDB ID: 6BM4 


Title:

POL II ELONGATION COMPLEX WITH AN ABASIC LESION AT I-1 POSITION,SOAKING UMPNPP

Molecular Description:

DNA-directed RNA polymerase II subunit RPB1
DNA-directed RNA polymerase II subunit RPB2
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerases I
II
and III subunit RPABC1
DNA-directed RNA polymerases I
II
and III subunit RPABC2
DNA-directed RNA polymerases I
II
and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I
II
and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11
DNA-directed RNA polymerases I
II
and III subunit RPABC4/DNA Complex

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 10 protein sequences

Primary Citation:

Wang, W., Walmacq, C., Chong, J., Kashlev, M., Wang, D.
Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. 
Proc. Natl. Acad. Sci. U.S.A., 115, pp. E2538 - E2545, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 168.72   b = 220.43   c = 193.15 (Ångstroms)

α = 90.0   β = 100.97   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2356 for 126204 reflections in the resolution range 55.607 to 2.951 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)