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NDB ID: 6BOT    PDB ID: 6BOT 


Title:

HUMAN APE1 SUBSTRATE COMPLEX WITH AN C/C MISMATCH ADJACENT THE THF

Molecular Description:

DNA-(apurinic or apyrimidinic site) lyase/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Fairlamb, M.S., Whitaker, A.M., Freudenthal, B.D.
Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. 
Acta Crystallogr D Struct Biol, 74, pp. 760 - 768, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 44.247   b = 60.944   c = 73.292 (Ångstroms)

α = 83.18   β = 78.48   γ = 87.21 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.204 for 62321 reflections in the resolution range 48.91 to 2.3 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)