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NDB ID: 6BRR    PDB ID: 6BRR 


Title:

CRYSTAL STRUCTURE OF DNMT3A (R836A)-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES

Molecular Description:

DNA (cytosine-5)-methyltransferase 3A
DNA (cytosine-5)-methyltransferase 3-like/DNA Complex

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Zhang, Z.M., Lu, R., Wang, P., Yu, Y., Chen, D., Gao, L., Liu, S., Ji, D., Rothbart, S.B., Wang, Y., Wang, G.G., Song, J.
Structural basis for DNMT3A-mediated de novo DNA methylation. 
Nature, 554, pp. 387 - 391, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 205.005   b = 205.005   c = 89.358 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2017 for 28270 reflections in the resolution range 19.955 to 2.97 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)