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NDB ID: 6BS1    PDB ID: 6BS1 


Title:

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA IN COMPLEX WITH DNA CONTAINING THE MAJOR CISPLATIN LESION

Molecular Description:

DNA polymerase kappa/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jha, V., Ling, H.
Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. 
J. Mol. Biol., 430, pp. 1577 - 1589, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 63.8   b = 127.72   c = 168.14 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.24705 for 21552 reflections in the resolution range 41.27 to 3.15 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)