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NDB ID: 6C1T    PDB ID: 6C1T 


Title:

MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA

Molecular Description:

Methyl-CpG-binding domain protein 2/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. 
J. Biol. Chem., 293, pp. 7344 - 7354, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 71.473   b = 36.933   c = 104.076 (Ångstroms)

α = 90.0   β = 108.25   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2153 for 21271 reflections in the resolution range 49.0 to 1.84 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)