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NDB ID: 6C64    PDB ID: 6C64 


Title:

CRYSTAL STRUCTURE OF THE MANGO-II FLUORESCENT APTAMER BOUND TO TO3-BIOTIN

Molecular Description:

RNA (36-MER)
RNA (32-MER)

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Trachman 3rd., R.J., Abdolahzadeh, A., Andreoni, A., Cojocaru, R., Knutson, J.R., Ryckelynck, M., Unrau, P.J., Ferre-D'Amare, A.R.
Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness. 
Biochemistry, 57, pp. 3544 - 3548, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 37.098   b = 181.764   c = 108.289 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.196349 for 7735 reflections in the resolution range 46.5152 to 3.00015 Ångstroms with Fobs >  1.34562 sigma(Fobs) and with I >  0.0 sigma(I)