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NDB ID: 6C65    PDB ID: 6C65 


Title:

CRYSTAL STRUCTURE OF THE MANGO-II-A22U FLUORESCENT APTAMER BOUND TO TO1-BIOTIN

Molecular Description:

RNA (36-MER)
RNA (35-MER)

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Trachman 3rd., R.J., Abdolahzadeh, A., Andreoni, A., Cojocaru, R., Knutson, J.R., Ryckelynck, M., Unrau, P.J., Ferre-D'Amare, A.R.
Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness. 
Biochemistry, 57, pp. 3544 - 3548, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 36.639   b = 179.68   c = 108.313 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.191169 for 9216 reflections in the resolution range 46.3812 to 2.80005 Ångstroms with Fobs >  1.34285 sigma(Fobs) and with I >  0.0 sigma(I)