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NDB ID: 6CMN    PDB ID: 6CMN 


Title:

CO-CRYSTAL STRUCTURE OF HIV-1 TAR BOUND TO LAB-EVOLVED RRM TBP6.7

Molecular Description:

TAR-Binding Protein 6.7/RNA Complex

Structural Keywords:

A DOUBLE HELIX, LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Belashov, I.A., Crawford, D.W., Cavender, C.E., Dai, P., Beardslee, P.C., Mathews, D.H., Pentelute, B.L., McNaughton, B.R., Wedekind, J.E.
Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. 
Nucleic Acids Res., 46, pp. 6401 - 6415, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 40.422   b = 40.422   c = 284.558 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1907 for 23278 reflections in the resolution range 37.187 to 1.796 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)