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NDB ID: 6CNP    PDB ID: 6CNP 


Title:

CRYSTAL STRUCTURE OF MBD2 COMPLEX WITH METHYLATED CPG ISLAND

Molecular Description:

Methyl-CpG-binding domain protein 2/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Liu, K., Xu, C., Lei, M., Yang, A., Loppnau, P., Hughes, T.R., Min, J.
Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. 
J. Biol. Chem., 293, pp. 7344 - 7354, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 40.96   b = 41.32   c = 58.67 (Ångstroms)

α = 101.57   β = 99.46   γ = 100.54 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1906 for 40927 reflections in the resolution range 39.457 to 2.1 Ångstroms with Fobs >  1.92 sigma(Fobs) and with I >  0.0 sigma(I)