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NDB ID: 6CT9    PDB ID: 6CT9 


Title:

STRUCTURE OF THE HUMAN CGAS-DNA COMPLEX

Molecular Description:

Cyclic GMP-AMP synthase/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhou, W., Whiteley, A.T., de Oliveira Mann, C.C., Morehouse, B.R., Nowak, R.P., Fischer, E.S., Gray, N.S., Mekalanos, J.J., Kranzusch, P.J.
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. 
Cell, 174, pp. 300 - 311.e11, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61 2 2

Cell Constants:

a = 99.782   b = 99.782   c = 236.769 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2021 for 33166 reflections in the resolution range 45.975 to 2.26 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)