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NDB ID: 6CTO    PDB ID: 6CTO 


Title:

TERNARY COMPLEX CRYSTAL STRUCTURE OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER WITH CF2, BETA, GAMMA DTTP ANALOGUE

Molecular Description:

DNA polymerase beta/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Batra, V.K., Oertell, K., Beard, W.A., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Wilson, S.H.
Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. 
Biochemistry, 57, pp. 3934 - 3944, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 50.784   b = 79.168   c = 55.494 (Ångstroms)

α = 90.0   β = 107.1   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1832 for 23556 reflections in the resolution range 19.792 to 2.04 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)