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NDB ID: 6CUU    PDB ID: 6CUU 


Title:

THERMUS THERMOPHILES RNA POLYMERASE IN COMPLEX WITH PROMOTER DNA AND ANTIBIOTIC KANGLEMYCIN A

Molecular Description:

DNA-directed RNA polymerase subunit alpha
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
DNA-directed RNA polymerase subunit omega
RNA polymerase sigma factor SigA/DNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 5 protein sequences

Primary Citation:

Mosaei, H., Molodtsov, V., Kepplinger, B., Harbottle, J., Moon, C.W., Jeeves, R.E., Ceccaroni, L., Shin, Y., Morton-Laing, S., Marrs, E.C.L., Wills, C., Clegg, W., Yuzenkova, Y., Perry, J.D., Bacon, J., Errington, J., Allenby, N.E.E., Hall, M.J., Murakami, K.S., Zenkin, N.
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. 
Mol. Cell, 72, pp. 263 - 274.e5, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 185.221   b = 101.315   c = 294.279 (Ångstroms)

α = 90.0   β = 98.89   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.202 for 107361 reflections in the resolution range 46.305 to 2.994 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)