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NDB ID: 6CUU    PDB ID: 6CUU 


Title:

THERMUS THERMOPHILES RNA POLYMERASE IN COMPLEX WITH PROMOTER DNA AND ANTIBIOTIC KANGLEMYCIN A

Molecular Description:

DNA-directed RNA polymerase subunit alpha
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
DNA-directed RNA polymerase subunit omega
RNA polymerase sigma factor SigA/DNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 5 protein sequences

Primary Citation:

Mosaei, H., Molodtsov, V., Kepplinger, B., Ceccaroni, L., Shin, Y., Morton, S., Wills, C., Clegg, W., Marrs, E., Perry, J., Harbottle, J., Yuzenkova, Y., Errington, J., Allenby, N., Hall, M.J., Murakami, K.S., Zenkin, N.
Mode of action of kanglemycin A, a new antibiotic targeting bacterial RNA polymerase
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 185.221   b = 101.315   c = 294.279 (Ångstroms)

α = 90.0   β = 98.89   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.202 for 107361 reflections in the resolution range 46.305 to 2.994 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)