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NDB ID: 6CVO    PDB ID: 6CVO 


Title:

HUMAN APRATAXIN (APTX) BOUND TO NICKED RNA-DNA, AMP AND ZN PRODUCT COMPLEX

Molecular Description:

Aprataxin/DNA Complex

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Tumbale, P., Schellenberg, M.J., Mueller, G.A., Fairweather, E., Watson, M., Little, J.N., Krahn, J., Waddell, I., London, R.E., Williams, R.S.
Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. 
EMBO J., 37, pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 58.913   b = 72.547   c = 147.164 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1856 for 25382 reflections in the resolution range 43.673 to 2.4 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)