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NDB ID: 6CVQ    PDB ID: 6CVQ 


Title:

HUMAN APRATAXIN (APTX) H201Q BOUND TO RNA-DNA, AMP AND ZN PRODUCT COMPLEX

Molecular Description:

Aprataxin/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Tumbale, P., Schellenberg, M.J., Mueller, G.A., Fairweather, E., Watson, M., Little, J.N., Krahn, J., Waddell, I., London, R.E., Williams, R.S.
Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. 
EMBO J., 37, pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 40.571   b = 116.049   c = 117.215 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1204 for 99412 reflections in the resolution range 32.409 to 1.65 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)