A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 19-Sep-2018 number of released structures: 9779
Search for released structures

NDB ID: 6CVS    PDB ID: 6CVS 


Title:

HUMAN APRATAXIN (APTX) L248M BOUND TO DNA, AMP AND ZN PRODUCT

Molecular Description:

Aprataxin/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Tumbale, P., Schellenberg, M.J., Mueller, G.A., Fairweather, E., Watson, M., Little, J.N., Krahn, J., Waddell, I., London, R.E., Williams, R.S.
Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. 
EMBO J., 37, pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 40.384   b = 116.316   c = 117.559 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.175 for 31247 reflections in the resolution range 28.889 to 2.11 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)