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NDB ID: 6CXZ    PDB ID: 6CXZ 


Title:

RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U.

Molecular Description:

RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3')

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Harp, J.M., Guenther, D.C., Bisbe, A., Perkins, L., Matsuda, S., Bommineni, G.R., Zlatev, I., Foster, D.J., Taneja, N., Charisse, K., Maier, M.A., Rajeev, K.G., Manoharan, M., Egli, M.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. 
Nucleic Acids Res., 46, pp. 8090 - 8104, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 30.46   b = 30.46   c = 81.889 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1877 for 6672 reflections in the resolution range 24.439 to 1.5 Ångstroms with Fobs >  0.27 sigma(Fobs) and with I >  0.0 sigma(I)