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NDB ID: 6CYT    PDB ID: 6CYT 


Title:

HIV-1 TAR LOOP IN COMPLEX WITH TAT:AFF4:P-TEFB

Molecular Description:

Cyclin-dependent kinase 9
Cyclin-T1
AF4/FMR2 family member 4
Protein Tat/RNA Complex

Deposited:

2018-04-06

Released:

2018-12-12

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Schulze-Gahmen, U., Hurley, J.H.
Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex. 
Proc. Natl. Acad. Sci. U.S.A., 115, pp. 12973 - 12978, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 148.58   b = 148.58   c = 104.63 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.251 for 17060 reflections in the resolution range 128.674 to 3.5 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)