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NDB ID: 6D0Z    PDB ID: 6D0Z 


Title:

POLYMERASE ETA CYTARABINE (ARAC) EXTENSION TERNARY COMPLEX

Molecular Description:

DNA polymerase eta/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Rechkoblit, O., Choudhury, J.R., Buku, A., Prakash, L., Prakash, S., Aggarwal, A.K.
Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine. 
Sci Rep, 8, pp. 12702 - 12702, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 98.789   b = 98.789   c = 81.772 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1697 for 45739 reflections in the resolution range 59.113 to 1.75 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)