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NDB ID: 6DB8    PDB ID: 6DB8 


Title:

STRUCTURAL BASIS FOR PROMISCUOUS BINDING AND ACTIVATION OF FLUOROGENIC DYES BY DIR2S RNA APTAMER

Molecular Description:

Fab-Heavy chain
Fab-Light chain/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Shelke, S.A., Shao, Y., Laski, A., Koirala, D., Weissman, B.P., Fuller, J.R., Tan, X., Constantin, T.P., Waggoner, A.S., Bruchez, M.P., Armitage, B.A., Piccirilli, J.A.
Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. 
Nat Commun, 9, pp. 4542 - 4542, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 109.158   b = 118.442   c = 119.31 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.219692 for 63984 reflections in the resolution range 37.59 to 1.86541 Ångstroms with Fobs >  1.33646 sigma(Fobs) and with I >  0.0 sigma(I)