A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 18-Jul-2019 number of released structures: 10288
Search for released structures

NDB ID: 6EDB    PDB ID: 6EDB 


Title:

CRYSTAL STRUCTURE OF SRY.HCGAS-21BP DSDNA COMPLEX

Molecular Description:

Sex-determining region Y protein
Cyclic GMP-AMP synthase/DNA Complex

Deposited:

2018-08-09

Released:

2019-05-29

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Xie, W., Lama, L., Adura, C., Tomita, D., Glickman, J.F., Tuschl, T., Patel, D.J.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. 
Proc.Natl.Acad.Sci.USA, 116, pp. 11946 - 11955, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 90.307   b = 115.827   c = 159.077 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2598 for 12629 reflections in the resolution range 30.008 to 3.209 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)