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NDB ID: 6EDC    PDB ID: 6EDC 


Title:

HCGAS-16BP DSDNA COMPLEX

Molecular Description:

Cyclic GMP-AMP synthase/DNA Complex

Deposited:

2018-08-09

Released:

2019-05-29

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Xie, W., Lama, L., Adura, C., Tomita, D., Glickman, J.F., Tuschl, T., Patel, D.J.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. 
Proc.Natl.Acad.Sci.USA, 116, pp. 11946 - 11955, 2019.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61 2 2

Cell Constants:

a = 99.813   b = 99.813   c = 238.644 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2409 for 19571 reflections in the resolution range 86.441 to 2.712 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)