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NDB ID: 6ERG    PDB ID: 6ERG 


Title:

COMPLEX OF XLF AND HETERODIMER KU BOUND TO DNA

Molecular Description:

X-ray repair cross-complementing protein 6
X-ray repair cross-complementing protein 5
XLF/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Nemoz, C., Ropars, V., Frit, P., Gontier, A., Drevet, P., Yu, J., Guerois, R., Pitois, A., Comte, A., Delteil, C., Barboule, N., Legrand, P., Baconnais, S., Yin, Y., Tadi, S., Barbet-Massin, E., Berger, I., Le Cam, E., Modesti, M., Rothenberg, E., Calsou, P., Charbonnier, J.B.
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. 
Nat. Struct. Mol. Biol., 25, pp. 971 - 980, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 111.71   b = 114.26   c = 127.17 (Ångstroms)

α = 90.0   β = 93.14   γ = 90.0 (degrees)

Refinement:

The structure was refined using the BUSTER program. The R value is 0.22 for 51644 reflections in the resolution range 48.76 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)