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NDB ID: 6EVV    PDB ID: 6EVV 


Title:

X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA THROMBIN AND NU172, A DUPLEX/QUADRUPLEX 26-MER DNA APTAMER, IN THE PRESENCE OF POTASSIUM IONS.

Molecular Description:

Prothrombin/DNA Complex

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Troisi, R., Napolitano, V., Spiridonova, V., Russo Krauss, I., Sica, F.
Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer. 
Nucleic Acids Res., , pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 67.875   b = 113.595   c = 208.034 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.1708 for 25367 reflections in the resolution range 104.02 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)