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NDB ID: 6F57    PDB ID: 6F57 


Title:

CRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH SINGLE CPG-CONTAINING DNA

Molecular Description:

DNA (cytosine-5)-methyltransferase 3A
DNA (cytosine-5)-methyltransferase 3-like/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Zhang, Z.M., Lu, R., Wang, P., Yu, Y., Chen, D., Gao, L., Liu, S., Ji, D., Rothbart, S.B., Wang, Y., Wang, G.G., Song, J.
Structural basis for DNMT3A-mediated de novo DNA methylation. 
Nature, 554, pp. 387 - 391, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 176.611   b = 49.559   c = 162.259 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2133 for 26650 reflections in the resolution range 47.72 to 3.098 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)