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NDB ID: 6FHH    PDB ID: 6FHH 


Title:

CRYSTAL STRUCTURE OF BAT INFLUENZA A/H17N10 POLYMERASE WITH VIRAL RNA PROMOTER BOUND TO A 22-MER MODIFIED POL II CTD PEPTIDE WITH SERINE 5 THIOPHOSPHORYLATED.

Molecular Description:

Polymerase acidic protein
RNA-directed RNA polymerase catalytic subunit
Polymerase basic protein 2/RNA Complex

Deposited:

2018-01-14

Released:

2019-01-30

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 5 protein sequences

Primary Citation:

Claron, M., Lukarska, M., Uhrig, U., Sehr, P., Drncova, P., Lewis, J.D., Will, D.W., Cusack, S.
Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 267.77   b = 147.81   c = 88.41 (Ångstroms)

α = 90.0   β = 97.08   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.21514 for 87532 reflections in the resolution range 50.0 to 2.7 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)