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NDB ID: 6FKR    PDB ID: 6FKR 


Title:

CRYSTAL STRUCTURE OF THE DOLPHIN PROLINE-RICH ANTIMICROBIAL PEPTIDE TUR1A BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME

Molecular Description:

50S ribosomal protein L2
50S ribosomal protein L3
50S ribosomal protein L4
50S ribosomal protein L5
50S ribosomal protein L6
50S ribosomal protein L9
50S ribosomal protein L13
50S ribosomal protein L14
50S ribosomal protein L15
50S ribosomal protein L16
50S ribosomal protein L17
50S ribosomal protein L18
50S ribosomal protein L19
50S ribosomal protein L20
50S ribosomal protein L21
50S ribosomal protein L22
50S ribosomal protein L23
50S ribosomal protein L24
50S ribosomal protein L25
50S ribosomal protein L27
50S ribosomal protein L28
50S ribosomal protein L29
50S ribosomal protein L30
50S ribosomal protein L31
50S ribosomal protein L32
50S ribosomal protein L33
50S ribosomal protein L34
50S ribosomal protein L35
50S ribosomal protein L36
30S ribosomal protein S2
30S ribosomal protein S3
30S ribosomal protein S4
30S ribosomal protein S5
30S ribosomal protein S6
30S ribosomal protein S7
30S ribosomal protein S8
30S ribosomal protein S9
30S ribosomal protein S10
30S ribosomal protein S11
30S ribosomal protein S12
30S ribosomal protein S13
30S ribosomal protein S14 type Z
30S ribosomal protein S15
30S ribosomal protein S16
30S ribosomal protein S17
30S ribosomal protein S18
30S ribosomal protein S19
30S ribosomal protein S20
30S ribosomal protein Thx
Tur1A peptide
Ribosome-associated factor Y/RNA Complex

Deposited:

2018-01-24

Released:

2018-03-28

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 51 protein sequences

Primary Citation:

Mardirossian, M., Perebaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Muller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N.
The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome. 
Cell Chem Biol, 25, pp. 530 - 539.e7, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 209.68   b = 449.25   c = 621.9 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1929 for 941410 reflections in the resolution range 49.757 to 3.2 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)